是否为危控品: 否生产企业:Relia Tech 密度:纯度:储存条件:零下20°C
产品描述说明:VEGF-C152S is a point mutant generated by the replacement of the second conserved Cys residue of the recombinant processed VEGF-C by a Ser residue. VEGF-C152S is analog to the human VEGF-C156S mutant and only active toward VEGFR-3/FLT-4 but, unlike wild type VEGF-C, is unable to bind to and to activate signaling through VEGFR-2/KDR. VEGF-C152S was inactive in the vascular permeability assay and did not increase migration of the capillary endothelial cells, indicating that these VEGF-like effects of VEGF-C require VEGFR-2 binding. VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The rat VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant rat VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant rat VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. The recombinant rat VEGF-C contains 127 amino acids residues and was fused to a His-tag (6x His) at the C-terminal end. As a result of glycosylation VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions. 品牌简介: 致力于开发与配体和受体相互作用相关的产品,包括人和鼠的重组细胞因子、 ELISA检测试剂盒、单克隆和多克隆抗体和功能性抗体等。
促甲状腺激素检测试剂盒(电化学发光法)
规格:200 tests
广口塑料桶
规格:2L
一次性口罩,民用口罩,三层过滤,50只/盒
规格:50只/盒
医用口罩,一次性医用口罩,三层防菌防病毒口罩,10只小袋 ,5袋/包
规格:10只/小袋 ,5袋/包
聚合物基质液相色谱柱
规格:250 x 4.6 mm, 5 μm
Atlantis T3 色谱柱
规格:5um 4.6x250mm
样品瓶
规格:盒
ExpressPlus™ PAGE Gel,10×8, 4-20%, 12 wells
规格:1Box of 10
谷丙转氨酶测定试剂盒(IFCC法)
规格:R1:520ml